Cubed by Nikil Saval goes into some of that very material. Of course, when my employer starts using terms such as “increasing employee engagement”, my Spidey sense starts tingling…

Virtually nothing about a modern office environment — and I’ve worked in my share — is natural, normal or conducive to human health.

Thankfully, some employers are willing to work with employees on ergonomics — i.e. standing desks, better chairs — but doctors don’t say “sitting is the new smoking” for nada.

And simple immobility is terrible for us. Likewise being crammed together in boxes with other disease-carrying animals, which goes to your first point.

But I would argue the worst damage is psychological. Many of us are fortunate enough to do work we (at least somewhat) enjoy. But in truth, the extreme division of labor reflected in the modern office environment is oppressive to human brains.